Apply a pea-size amount of the product in the evening to clean, dry face and neck, avoiding the eye area. Gently massage until fully absorbed. Start by using it once a week and gradually increase the frequency as your skin builds tolerance. For best results, apply it after a hydrating serum, such as REVOX B77 Hyaluronic Acid 5% or REVOX B77 JUST Polyglutamic Acid, and before a moisturizer. You can also use the "retinal sandwich" method: apply a light layer of REVOX B77 JUST Provitamin B5 and Centella before and after the retinal to help minimize irritation and keep your skin hydrated. Combine with: JUST Provitamin B5 and Centella / JUST Hyaluronic Acid 5% . Don´t combine with: Do not combine with exfoliants and other retinol products. Caution Individual intolerance to the product is possible. If discomfort occurs, discontinue the use of the product. Before the first application, it is recommended to performa sensitivity test. Avoid prolonged sun exposure! It is advised to use sun protection in the morning!